Profil de ChaunceyEven nOw thEre is stilL ...PhotosBlogListesPlus ![]() | Aide |
Even nOw thEre is stilL hope left~~~
|
||||||||||||
|
23 novembre 那碗粥收集齐了 小谢的歌曲, 喜帖街 竟然有国语版 不过非常令人失望,远远没有 粤语版达到的意境. "忘掉种过的花,重新的出发,放弃理想吧."但是下面这首国语版, 周博賢老师对歌词的把握做的不错比其粤语版又有了几分味道.那碗粥 (國)
安靜的一年 慢慢溜過雙手 下了班之後 6 octobre 2009 Nobel Prize in Physiology or MedicineThe 2009 Nobel Prize in Physiology or Medicine will go to three Americans who discovered telomeres, the genetic code that protects the ends of chromosomes, and telomerase, the enzyme that assists in this process, findings that are important in the study of cancer, aging and stem cells. Announced this morning in Stockholm, the three geneticists—Elizabeth Blackburn, a professor of biology and physiology at the University of California, San Francisco, Carol Greider, a professor in the department of molecular biology and genetics at Johns Hopkins University School of Medicine in Baltimore, and Jack Szostak, a professor of genetics at Massachusetts General Hospital in Boston, who are all previous Scientific American authors—will split the award of 10 million Swedish kronor (about $1.4 million), along with the prestige and honor. The work for which they received the award illuminated key aspects of the DNA replication process. As genetic material is copied from the chromosome—a process crucial to the daily maintenance of cellular life—the whole DNA strand must be duplicated from end to end, otherwise, portions of genetic information will be lost. Until the 1980s, it was a mystery as to how the chromosomes could be reliably copied the whole way through without missing bits and pieces at the very end of each strand. Work completed by this year’s laureates demonstrated how, if parts of the end-cap telomeres were missing, DNA would eventually be shortened and cut off in the replication process. Blackburn and Szostak, who had been studying the ends of chromosomes and minichromosomes respectively, met at a conference in 1980, after which they began collaborating. Two years later, they demonstrated in a paper published in Cell that the telomere sequence could be isolated, inserted into another organism and still serve the same function. Working with Blackburn, Greider helped in 1989 to identify the RNA-based telomerase—the enzyme that creates the crucial telomeres—in a paper published in Nature. (Scientific American is part of the Nature Publishing Group.) The findings have since been applied in studies of aging, stem cells and cancer. Early research by Blackburn and Szostak showed that if telomeres were shortened it would lead to slower cell division and premature aging in yeast—and later in human cells. Since the early discoveries, defective telomeres have also been found to play a role in some forms of inherited anemia, as they affect the division of bone marrow stem cells. Cancer may also be in part a disease of telomere dysfunction. Given the rapid rate of division among cancer cells, they have been a more recent target of telomere research. Treatments taking advantage of this new knowledge are in clinical trails—the data from which are still outstanding—noted the Nobel committee. Although findings related to this research have been generating much excitement in the field of cancer research—as well as that of aging—those issuing the award note that much study remains to be done. "Now it will be very important to figure out what is real, what is mechanism and what is statistical noise," said Goran Hansson, a professor of cardiology at the Karolinska Institute and member of the Prize committee, said during the announcement press briefing. For the researchers, much of the early discoveries were driven by general curiosity about the workings of chromosomes and DNA replication. "We had no idea when we started this work that telomerase would be involved in cancer, but were simply curious about how chromosomes stayed intact," Greider said in a statement after winning the Lasker Award in 2006 for some of the same research. "Our approach shows that while you can do research that tries to answer specific questions about a disease, you can also just follow your nose." Jeremy Berg, director of the National Institute of General Medical Sciences was pleased to see an example of general research chosen for the prize. He calls it "A great example of a curiosity-driven process. " The selection of telomeres research was not a surprise to many in the field, he says, as the research has "been moving along steadily under its own power… [and] everybody had known how important it was. " Nevertheless, there are some large questions that remain to be answered about the workings of telomeres and the associated telomerase—in addition to results from the ongoing clinical trials. From an evolutionary standpoint, for example, the similarities between telomerase and the reverse transcriptase in retroviruses and living telomeres-less knockout mice beg for further study, Berg notes. This is the first time in the prize's 108-year history that more than one woman has been awarded the prize in medicine in a single year. Only eight other women have won the medical Nobel. Last year's Nobel Prize in Physiology or Medicine was shared by Harald zur Hausen—for his work discovering the link between the HPV (the human papilloma virus) and cervical cancer—and Francoise Barre Sinoussi and Luc Montagnier—for their joint discovery of HIV (the human immunodeficiency virus).14 septembre Bio Bio life begins今天来锄草 不知不觉,开学2周了,不知不觉,来到这里1个多月了, 不知不觉,自己开着车跑了2周了, 美国同学说我很潇洒,刚来买了brand new car,在这个经济萧条的年代, 中国同学说你买coupe打算追女么, 我只知道,我每早已经不需要闹铃,6点半醒来,做早餐,摩咖啡豆煮咖啡(不是我喜欢,为的是8点课不要睡着),下意识的一路油门,University Oaks, George Bush East, George Bush Dr. Wellborn Rd, 然后WestCampus停车楼盘旋着向上找车位. 我只知道,每堂课后下意识的走向西区图书馆,看书,等下一节课. 我只知道,每晚要漆黑中开车回家,孤独的人,孤独的车,音响中飘荡着"单车"........ 系里教授说,做science一定要求高,要tough, Correct. 是tough,我只知道28个新生,2周已经一个美国女生quit. oh,yeah,每个月A&M的最高的奖学金,又如何,性价比如此之低下,都没有时间让你去花. 周末?我只记得第一个周末我在图书馆和Ryan,Alvin,Rho呆了一天,讨论paper. 有点麻木, 下午去了6号高速那边的体育用品店,买了棒球棒和手套,下次系里比赛可以用自己装备了.说来搞笑.喜欢棒球是因为赌球.因为赌球而研究棒球.研究MLB,到熟悉里面大部分的球员,球队.Nerd 昨晚,今天,感觉自己都处于一个,很容易爆发的状态,很想打架的状态. " 忘掉种过的花 重新的出发 放弃理想吧 " 无意中看到,突然意识到是我喜欢听的那首歌的歌词, 旋律在我脑中盘旋,想到说此话之人此时可能处的情景, 对以前同学说句 幻灭的阵痛是不可避免的,但是生活 要继续 28 juin 游记之二奥运帆船基地之后, 晚上去了个青岛啤酒自己开的酒吧,气氛很high,爸爸和朋友都喝大了,不喝大也不行阿.那个酒吧的表演很精彩.一个家伙模仿MJ的经典动作维妙维肖,算是另类的怀念了.还有印象的就是艳舞表演了,哈哈.. Day2 海军博物馆 五四广场 爸爸的朋友的司机累了不想走路,偶就和他说找个停车场停下来,我自己去玩吧,还是自己一个人舒服. 我自己去参观了下老城区,德国建筑,不过坏处是天气太热了,胳膊被晒伤了,一级烧伤阿..... Day3 继续自己晃悠,在咖啡厅看了会书,把后面几天杭州苏州的行程大体有了个计划. |
|
|||||||||||
|
||||||||||||
|
|